A Research Laboratory of Neuroimmunology, Neurotrauma, and Behavior

Copyright © Godbout Laboratory. All rights reserved.

Copyright © Godbout Laboratory. All rights reserved.

Peer-Reviewed Publications:
McKim, D., Weber, M., Niraula, A., Sawicki C., Liu, X., Jarrett, B., Ramirez-Chan, K., Roeth, R., Sucaldito, A., Sobol, C., Quan, N., Sheridan, J.F. and Godbout, J.P.  (2017) Microglial recruitment of IL-1beta producing monocytes to brain endothelium causes stress-induced anxiety.  Mol Psychiatry. 2017 Apr 4. doi: 10.1038/mp.2017.64. (IF: 14.5)

 Witcher, K.G., and Godbout, J.P. (2017) Can sustained glial-mediated brain inflammation with repeated concussive brain injury be detected in vivo? Commentary: JAMA-Neurology.  Jan 1;74(1):23-25. doi: 10.1001/jamaneurol.2016.4539. (IF.8.230)


Bolyard, C, Meisen, HW, Hardcastle, J, Yoo, JY, Wohleb,. ES, Wojton, J., Dubin, S., Khosla, M., Alvarez-Breckenridge, C., Pow-anpongkul, P., Zhang JY, Old. M., Godbout, J.P., Caligiuri, M, Yu, J., and Kaur, B. (2017). BAI1 orchestrates macrophage immune responses to HSV infection- implications for oncolytic viral therapy. Clinical Cancer Research 2017 Apr 1;23(7):1809-1819. doi: 10.1158/1078-0432.CCR-16-1818. Epub 2016 Nov 9.] (IF: 8.74)


Niraula, A., Sheridan, J. and Godbout, JP (2016) Microglial Priming in Aging and Stress.  Invited review for Neuropsychopharmacology, Sep 8. doi: 10.1038/npp.2016.185. [Epub ahead of print] (IF: 7.05)

Pyter LM, Husain Y, Calero H, McKim DB, Lin HY, Godbout, J.P. Sheridan JF, Engeland CG, Marucha PT. (2016) Tumors Alter Inflammation and Impair Dermal Wound Healing in Female Mice.PLoS One. 2016 Aug 22;11(8):e0161537. doi: 10.1371/journal.pone.0161537. (IF: 3.323)

Norden, D.M., Trojanowski, P.T, Walker, F.R., and Godbout, J.P. (2016) Insensitivity of Astrocytes to Interleukin-10 Re-programming following Peripheral Immune Challenge Results in Prolonged Microglia Activation in the Aged Brain. Neurobiology of Aging. 44:22-41I (IF: 5.013)

 Weber, M. Godbout, JP and Sheridan (2016) Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal.  Neuropsychopharmacology, Jul 20. doi: 10.1038/npp.2016.102. [Epub ahead of print] Review (IF: 7.05)

 Hansen C.N., Norden, D.M., Faw, T.D., Deibert, R., Wohleb, E.S., Sheridan, J.F., Godbout, J.P., Basso., D.M. (2016) Lumbar Myeloid Cell Trafficking into Locomotor Networks after Thoracic Spinal Cord Injury. Experimental Neurology 282:86-98 (IF 4.7)

 Fonken, L., Frank, M., Kitt, M., D’Angelo, H., Norden, DM, Weber, M., Barrientos, R., Godbout, J.P., Watkins, LR & Maier, S. (2016) The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming.  Journal of Neuroscience, Jul 27;36(30):7946-56. doi: 10.1523/JNEUROSCI.1161-16. (IF: 6.34)

 Ziebell, JM, Rowe, RK, Muccigrosso, M., Reddaway, JT, Adelson, PD, Godbout, J.P and Lifshitz, J. (2016)   Aging With a Traumatic Brain Injury: Could Behavioral Morbidities and Endocrine Symptoms be Influenced by Microglial Priming? Brain Behavior and Immunity S0889-1591(16)30053-8. doi: 10.1016/j.bbi.2016.03.008. [Epub ahead of print] Review.PMID:26975888. (IF.6.1)

 DiSabato, D., Quan, N., and Godbout, J.P. (2016) Neuroinflammation: The Devil is in the Details.  Invited review for Journal of Neurochemistry  Mar 15. doi: 10.1111/jnc.13607. [Epub ahead of print] Review.

McKim, D., Niraula, A., Tarr, A., Wohleb, E., Sheridan, J., and Godbout, J.P. (2016) Neuroinflammatory Dynamics Underlie Memory Impairments after Repeated Social Defeat. Journal of Neuroscience, Mar 2;36(9):2590-604. doi: 10.1523/JNEUROSCI.2394-15.2016. (IF: 6.34)

Muccigrosso, M.M., Ford, J., Benner, B., Moussa, D., Burnsides, C., Fenn, A.M., Popovich, P.G., Lifshitz, J., Walker, F.R, Eiferman, D.S., and Godbout, J.P. (2016) Cognitive impairment develops 1 month after mTBI and is exaggerated by Microglia-Associated Reactivity to Peripheral Immune Challenge. Brain Behavior and Immunity (IF 6.1)


Witcher, K.G., Eiferman, D.E., and Godbout, J.P (2015) Priming the Inflammatory Pump of the CNS after Traumatic Brain Injury. Invited review for Trends in Neuroscience Oct;38(10):609-20. doi: 10.1016/j.tins.2015.08.002. Review. (IF 12.9)


Norden, D, Trojanowski, P. Villanueva, E., Navarro, E., and Godbout, J.P. (2015) “Sequential Activation of Microglia and Astrocyte Cytokine Expression Precedes Increased Iba-1 or GFAP Immunoreactivity following Systemic Immune Challenge” Glia, Feb;64(2):300-16. doi: 10.1002/glia.22930. Epub 2015 Oct 15. (IF 6.03)


McKim, D. Patterson, J., Wohleb, E., Jarrett, B., Reader, B., Godbout, J.P. and Sheridan, J.F.  (2015)Sympathetic Release of Splenic Monocytes Promotes Recurring Anxiety Following Repeated Social Defeat. Biological Psychiatry (IF: 9.25) 

Skendelas, J., Muccigrosso, M.M., Eiferman, D.S., and Godbout, J.P. (2015) Chronic Inflammation after TBI and Associated Behavioral Sequelae.  Current Physical Medicine and Rehabilitation Reports

Meisen, MH, Wohleb, E, Jaime-Ramirez, AC, Bolyard, C, Yoo, JY, Russell, L., Hardcastle, J., Dubin, S,  Godbout, JP and Kaur, B. (2015) The impact of macrophage and microglia secreted TNFα on oncolytic viral therapy in the glioblastoma tumor microenvironment. Clinical Cancer Research, 2015 July, 15. doi: 10.1158/1078-0432.CCR-14-3118. Epub 2015 Mar 31 (IF:8.2)

Reader, B., Jarrett, B., McKim, D., Wohleb, E., Godbout, J.P. and Sheridan, JF (2015) Peripheral and Central Effects of Repeated Social Defeat Stress: Monocyte Trafficking, Microglial Activation, and Anxiety. Neuroscience, 2015 Mar 19;289C:429-442. doi: 10.1016/j.neuroscience.2015.01.001. Epub 2015 Jan 14. 004 (IF 3.2)

Norden, D., Devine, R., Bicer, S., Jing, R., Reiser, P.J., Wold, L.E., Godbout, J.P., McCarthy, D.O. (2015) Fluoxetine Prevents the Development of Depressive-Like Behavior in a Mouse Model of Cancer Related Fatigue. Physiology and Behavior, 2015 Mar 1;140:230-5. doi: 10.1016/j.physbeh.2014.12.045. Epub 2014 Dec 30. (IF: 3.15)

Wohleb, E.*, McKim, D.*, Sheridan, J.F., and Godbout, J.P. (2015) Monocyte trafficking to the brain with stress and inflammation: A novel axis of immune-to-brain communication that influences mood and behavior Frontiers in Neuroscience, 2015 Jan 21;8:447. doi: 10.3389/fnins.2014.00447.

Liu X, Yamashita T, Chen Q, Belevych N, Mckim DB, Tarr AJ, Coppola V, Nath N, Nemeth DP, Syed ZW, Sheridan JF, Godbout JP, Zuo J, and Quan N. (2015) Interleukin 1 type 1 receptor restore: a genetic mouse model for studying interleukin 1 receptor-mediated effects in specific cell types. Journal of Neuroscience 2015 Feb 18;35(7):2860-70. (IF 7.1)

Norden, D., Muccigrosso, M.M., and Godbout, J.P. (2015) Microglial Priming and Enhanced Reactivity to Secondary Insult in Aging, Traumatic CNS Injury, and Neurodegenerative Disease.  Neuropharmacology 2014 Nov 13. pii: S0028-3908(14)00403-1. doi: 10.1016/j.neuropharm.2014.10.028 (IF 4.7).

Sawicki, C.M., McKim, D., Wohleb, E.S., Jarrett, B.L., Reader, B., Norden, D., Godbout, J.P. and Sheridan, J.F.  (2014) Social defeat promotes a reactive endothelium in a brain region-dependent manner with increased expression of key adhesion molecules, selectins and chemokines associated with the recruitment of myeloid cells to the brain. Neuroscience. 2014 Oct 14. pii: S0306-4522(14)00858-6. doi: 10.1016/j.neuroscience.2014.10.004 (IF 3.2)

 Norden, D., Bicer, S., Clark, Y., Jing, R., Henry, C.J., Wold, L., Reiser, P., Godbout, J.P. and McCarthy, DO. (2014) Tumor progression Increases Neuroinflammation, Fatigue, and Depressive-like behavior without Altering Muscle Function. Brain Behavior and Immunity. 2014 Aug 4. pii: S0889-1591(14)00405-X. doi: 10.1016/j.bbi.2014.07.013 (IF 6.1)

 Fenn, AM, Skendelas, J., Moussa, D., Mucigrosso, M., Lifshitz, J., Popovich, P.G., Eiferman, D.S., and J.P. Godbout (2015) Methylene Blue Attenuates Traumatic Brain Injury Associated Neuroinflammation and Acute Depressive-like Behavior in mice. Journal of Neurotrauma . 2015 Jan 15;32(2):127-38. doi: 10.1089/neu.2014.3514. Epub 2014 Nov 13. (IF 4.7)

 Fenn, A.M., Hall, J., Gensel, J., Popovich, P.G., and Godbout, J.P. (2014) IL-4 Signaling Drives a Unique Arginase+/IL-1β+Microglia Phenotype and Recruits Macrophages to the Inflammatory CNS: Consequences of Age-Related Deficits in IL-4Rα after Traumatic Spinal Cord Injury. Journal of Neuroscience 34(26):8904-8917 (IF 7.1)

 Norden, D., Fenn, A.M, Dugan, A., and Godbout, J (2014) TGFbeta produced by IL-10 re-directed Astrocytes Attenuates Microglial Activation.  Glia, Jun;62(6):881-95. doi: 10.1002/glia.22647. (IF 5.1)

 Frakes, A.E., Ferraiuolo, l., Haidet-Phillips, A.M., Schmelzer, L., Braun, L., Miranda, C. J., Bevan, A., Foust, K.D., Godbout, J.P., Popovich, P.G., Guttridge, D.C., and Kaspar, BK. (2014) Microglia induce motor neuron death via the classical NF-kB pathway in ALS. Neuron Mar 5;81(5):1009-23. doi: 10.1016/j.neuron.2014.01.013. (IF 15.7)

 Wohleb, E., Patterson, J.M., Sharma, V., Quan, N., Godbout, J.P. and Sheridan, J.F. (2014) Knock-down of interleukin-1 receptor type-1 (IL-1R1) on endothelial cells ameliorated stress-induced neuroinflammation and prevented anxiety-like behavior. Journal of Neuroscience, 34(7) 2583-2591 (IF 7.1)

 Wohleb, E., McKim, D., Shea, D., Tarr, A., Sheridan, J., and Godbout, J.P. (2014) Re-establishment of anxiety in stress-sensitized mice is caused by monocyte trafficking from the spleen to the brain. Biological Psychiatry Dec 10. pii: S0006-3223(13)01072-X. doi: 10.1016/j.biopsych.2013.11.029 (IF 9.25)

 Fenn, A.M., Gensel, J., Huang, Y., Popovich, P.G., Lifshitz, J., and Godbout, J.P. (2014) Immune activation promotes depression one month after brain injury: a role for primed microglia.  Biological Psychiatry 2013 Oct 25. doi:pii: S0006-3223(13)00950-5. 10.1016/j.biopsych.2013.10.014. (IF 9.25)

 Lieblein-Boff, J., McKim, D., Shea, D., Sawicki, C., Deng, Z., Bilbo, S.D., Bailey, M., Quan, N., McTigue, D.,  and Godbout, J.P. (2013) Neonatal E.coli infection causes neuro-behavioral deficits associated with hypomyelination and neuronal sequestration of iron. Journal of Neuroscience, Oct 9;33(41):16334-45. doi: 10.1523/JNEUROSCI.0708-13.2013. (IF 7.1)

 Wohleb, E.S., Powell, N.D., Godbout, J.P., and Sheridan, J.F. (2013) Stress-Induced Recruitment of Bone Marrow-Derived Monocytes to the Brain Promotes Anxiety-Like Behavior. Journal of Neuroscience, Aug 21;33(34):13820-33. doi: 10.1523/JNEUROSCI.1671-13.2013. (IF 7.1)

 Fenn, A.M., Smith, K Lovett-Racke, A, Gurau-de-Arellano, M., Whitacre C, and Godbout, J.P (2013). Increased miR-29b in the aged brain correlates with the reduction of IGF-1 and CX3CL1. Neurobiology of Aging EpubJul 20. doi:pii: S0197-4580(13)00262-5. 10.1016/j.neurobiolaging.2013.06.007. (IF 6.1).

Gomez-Nicola D, Teeling J, Guaza C, Godbout JP, Taub DD. (2013) The Role of Inflammatory Mediators in Immune-to-Brain Communication during Health and Disease. Mediators of Inflammation. 2013:429231. doi: 10.1155/2013/429231. Epub 2013 Sep 10. 


Brothers, H.M., Bardou, I.,  Hopp, S.C., Kaercher, R.M., Corona, A.W.,Fenn, A.M.,  Godbout, J.P. and Wenk, G.L. (2013) “
Riluzole Partially Rescues Age-Associated, but not LPS-Induced, Loss of Glutamate Transporters and Spatial Memory.” Journal of Neuroimmune Pharmacology. EpubMay 25. (IF 4.57).


Voorhees JL, Tarr AJ, Wohleb ES, Godbout JP, Mo X, Sheridan JF, Eubank, TD, Marsh CB. (2013) “Prolonged Restraint Stress Increases IL-6, Reduces IL-10,and Causes Persistent Depressive-like Behavior that is Reversed by Recombinant IL-10” PLoS One. 2013;8(3): PMC3592793 (IF 4.4).​

 Corona, A.W.,Skendelas, J., Norden, D., Huang, Y., O’Connor, J.C., Lawson, M., Dantzer, R., Kelley, K., and Godbout, J.P. (2013) “Indoleamine-2,3-dioxygenase inhibitionattenuates lipopolysaccharide induced persistent microglial activation anddepressive-like complications in fractalkine receptor (CX3CR1)-deficientmice”.  Brain, Behavior, and Immunity. Jul;31:134-42. PMC3554840. (IF 5.6).​

Norden,D. and Godbout, JP. (2013) “Microglia of the Aged Brain: Primed to be Activated and Resistant to Regulation”. Neuropathology and Applied Neurobiology.  Invited review for a Special Issue on thetopic of “Neuroinflammation in Neurodegeneration”. 2013 Feb;39(1):19-34. PMC3553257 (IF 3.95).

Wohleb, E.S., Fenn,A.M., Pacenta, A., Powell, N., Sheridan, J.F., and Godbout, J.P. (2012) “Peripheral lipopolysaccharide (LPS) injection
exaggerated microglial activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice
”. PsychoNeuroEndocrinology.  Sept;37(9):1491-505. PMC3368999 (IF 5.2).

Fenn, A.M., Henry, C., Huang, Y, Dugan, A., and Godbout, J.P. (2012) "Lipopolysaccharide-induced interleukin (IL)-4 receptor-alpha expression and corresponding sensitivity to the M2 promotingeffects of IL-4 are impaired in microglia of aged mice”. Brain, Behavior, and Immunity, Jul;26(5):766-77. PMC3288757 (IF 5.6).

Corona, A.W., Fenn, A.M., and Godbout,J.P. (2012) “Cognitive andbehavioral consequences of impaired immunoregulation in aging”. Journal
of Neuroimmune Pharmacology, Mar, 7(1), 7-23. (IF 3.5).

Wohleb, E., Hanke, M., Corona, A., Powell, N., Stiner, L.,Bailey, MT, Nelson, R., Godbout, JP,  and Sheridan, JF (2011) "β-Adrenergic Antagonism
Prevents Anxiety-like Behavior and CNS Macrophage/Microglial Reactivity Induced by Repeated Social Defeat. Journal of Neuroscience
". Vol. 31,
no. 17. (April 27): 6277-6288.  PMC3160240 (IF 7.2).

Corona,A.W., Huang, Y., O’Connor, J.C., Dantzer, R., Kelley, K., Popovich, PG, and Godbout, J.P. (2010) "Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide".  Journal of Neuroinflammation. 7:93. PMC3018416 (IF 4.6).

Wynne, A., Henry, C.J., Huang, Y., Cleland, A., Godbout, J.P. (2010) "Protracted downregulation of CX3CR1 on microglia of aged mice after
lipopolysaccharide challenge
". Brain,Behavior, and Immunity, Oct 24(7): 1190-1201. PMC2939290. (IF 5.1).

Wynne, A.,Henry, C.J. and Godbout, J.P. (2009) "Immune and behavioral consequences of microglial reactivity in the aged brain".  Integrative
and Comparative Biology.  49, 254-266 (IF 2.66).

Godbout, J.P. and Johnson, R.W. (2009) "Age and neuroinflammation: a lifetime of psychoneuroimmune consequences". Immunol Allergy Clin North Am.May;29(2):321-37. (IF 2.34).

Henry, C.J., Huang, Y., Wynne, A., and Godbout, J.P. (2009) "Peripheral Lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1b and anti-inflammatory IL-10 cytokines". Brain, Behavior, and Immunity.  23:309-317. PMC2692986 (IF 4.7).

Henry,C.J., Huang, Y., Wynne, A., Hanke, M., Himler, J., Bailey, M., Sheridan, J. and Godbout, J.P. (2008) "Minocycline attenuates lipopolysaccharide-induced neuroinflammation, sickness behavior, andanhedonia". Journal of Neuroinflammation, May 13;5:15. PMC2412862 (IF 4.77).​

Godbout, J.P., Moreau, M., Lestage, J., Sparkman, N., Chen, J., O’ Connor, J., Castanon, N., Kelley, K.W., Dantzer, R., and Johnson, RW (2008) "Aging exacerbates depressive like-behavior in mice in response to activation of the peripheral innate immune system". Neuropsychopharmacology, Sep;33(10):2341-51. PMC2907915 (IF 6.35).

Abraham, J., Jang, S., Godbout, J.P., Chen, J., and Johnson, R.W. (2008) "Aged mice are more sensitive to behavioral deficits induced by central
HIV-1 gp120
".  Neurobiology of Aging. 29,614-621. (IF 5.6).

Chen,J., Buchanan, J.B., Sparkman, N.L. Godbout, J.P., Freund, G., and Johnson, R.W. (2008) "Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system". Brain, Behavior, and Immunity. 22, 301-311.  (IF 5.1).

Huang, Y., Henry,C.J., Dantzer, R, Johnson, R.W., and Godbout,J.P. (2008) "Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide". Neurobiology of Aging, Nov;29(11):1744-53. PMC2647751. (IF 5.6).

Gaykema, R.P.A., Balachandran, M.K., Godbout, J.P., Johnson R.W., and Goehler,L.E. (2007) "Enhanced neuronal activation in central autonomic network nuclei of aged mice following acute peripheral immune challenge". Autonomic Neuroscience,Jan30;131(1-2):137-142. (IF 1.85).

Godbout,J.P. and Glaser, R. (2006) "Stress-Induced Immune Dysregulation:  Implications for Wound Healing, Infectious Disease and Cancer". Journal of Neuroimmune Pharmacology1, 421-427. 

Godbout,J.P. and Johnson, R.W. (2006) "Age and neuroinflammation: a lifetime of psychoneuroimmune consequences". Neurologic Clinics, 24, 512-538. (IF 2.51).

Godbout, J.P., Chen,J., Abraham, J., Richwine, A.R., Berg, B.M., Kelley,K.W., and Johnson, R.W. (2005) "Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system". FASEB Journal. Aug; 19(10):1329-31. (IF 6.8).

Godbout, J.P., Berg, B.M., Krzyszton, C., and Johnson, R.W. (2005). "a-Tocopherol attenuates NFkB activation andpro-inflammatory cytokine production in brain and improves recovery from lipopolysaccharide-induced sickness behavior".  Journal of Neuroimmunology. 169, 97-105. (IF 3.4).

Richwine, A.R., Godbout, J.P, Chen, J., Berg, B.M., Escobar, J.,Millard, D.K., and. Johnson, R.W. (2005) "Improved psychomotor performance in aged mice fed diet high in antioxidants is associated with reduced ex vivo interleukin-6 production". Brain, Behavior, and Immunity. 19, 512-520. (IF 5.1).

Berg, B.M., Godbout, J.P., Chen, J.,Kelley, K.W., and Johnson, R.W. (2005) "a-Tocopherol and Selenium facilitate recovery from lipopolysaccharide-induced sicknessbehavior in aged mice".  Journal ofNutrition, 135, 1157-1163 (IF 3.25).

Godbout, J.P., Berg, B.M., Kelley, K.W., and Johnson, R.W. (2004) "a-Tocopherol reduceslipopolysaccharide-induced peroxide radical accumulation and interleukin-6 secretion in primary murine microglia and in brain".  Journal of Neuroimmunology. 149, 101-109. (IF 3.34).

Godbout, J.P. and Johnson, R.W. (2004) "Interleukin-6 in the Aging Brain". Journal of Neuroimmunology. 147, 141-144. (IF 3.34).

Berg, B.M., Godbout, J.P., Kelley, K.W., and Johnson, R.W. (2004) "a-Tocopherol attenuates lipopolysaccharide-induced sickness behavior in mice". Brain, Behavior, andImmunity. 18, 149-157. (IF 4.7).

Hartman, M.E.,O’Connor J.C., Godbout, J.P., Minor, K.D., Mazzocco, V.R. and Freund, G.G. (2004) "Insulin Receptor Substrate-2-Dependent Interleukin-4 Signaling in Macrophages isImpaired in Two Models of Type 2 Diabetes Mellitus". Journal of Biological Chemistry. 279: 28. (IF 6.35).

Godbout, J.P., Pesavento, J., Hartman, M.E., Manson, S.R.,and Freund, G.G. (2002) "Methylglyoxal Enhances Cisplatin-Induced Cytotoxicity By Activating PKCd".  Journal of BiologicalChemistry. 277: 2554-2561. (IF 6.35).

Godbout, J.P., Cengel, K.A., Cheng, S., Minshall, C.,Kelley, K.W., and Freund, G.G. (1999) "Insulin activates caspase-3 by a phosphatidylinositol 3’-kinase dependent pathway". Cellular Signalling. 11:15-23. (IF 4.7).
​​
Cengel, K.A., Godbout, J.P.,and Freund, G.G. (1998) "Phosphatidylinositol 3'-kinase is associated with a serine kinase that is activated by okadaic acid". Biochemical and BiophysicalResearch Communications. 242: 513-517. (IF 2.94).